Apolipoprotein L1 (APOL1) renal risk variant-mediated podocyte cytotoxicity depends on African haplotype and surface expression
N Gupta, B Waas, D Austin, AM De Mazière… - Scientific Reports, 2024 - nature.com
Abstract Homozygous Apolipoprotein L1 (APOL1) variants G1 and G2 cause APOL1-
mediated kidney disease, purportedly acting as surface cation channels in podocytes …
mediated kidney disease, purportedly acting as surface cation channels in podocytes …
APOL1 nephropathy–a population genetics success story
O Tabachnikov, K Skorecki… - Current Opinion in …, 2024 - journals.lww.com
Notwithstanding remaining controversies and uncertainties, promising genomically precise
therapies targeted at APOL1 mRNA using antisense oligonucleotides (ASO), inhibitors of …
therapies targeted at APOL1 mRNA using antisense oligonucleotides (ASO), inhibitors of …
Body Fat Distribution Contributes to Defining the Relationship between Insulin Resistance and Obesity in Human Diseases
MM Adeva-Andany… - Current Diabetes …, 2024 - ingentaconnect.com
The risk for metabolic and cardiovascular complications of obesity is defined by body fat
distribution rather than global adiposity. Unlike subcutaneous fat, visceral fat (including …
distribution rather than global adiposity. Unlike subcutaneous fat, visceral fat (including …
The Two Levels of Podocyte Dysfunctions Induced by Apolipoprotein L1 Risk Variants
E Pays - Kidney and Dialysis, 2024 - mdpi.com
Apolipoprotein L1 (APOL1) nephropathy results from several podocyte dysfunctions
involving morphological and motility changes, mitochondrial perturbations, inflammatory …
involving morphological and motility changes, mitochondrial perturbations, inflammatory …
Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
J Pell, S Nagata, MC Menon - Kidney360, 2023 - journals.lww.com
Since the seminal discovery of the trypanolytic, exonic variants in apolipoprotein L1 (APOL1)
and their association with kidney disease in individuals of recent African ancestry, a wide …
and their association with kidney disease in individuals of recent African ancestry, a wide …
In Search of the Mechanism of APOL1 Kidney Disease
DJ Friedman, MR Pollak - Journal of the American Society of …, 2024 - journals.lww.com
Journal of the American Society of Nephrology Page 1 Journal of the American Society of
Nephrology In Search of the Mechanism of APOL1 Kidney Disease --Manuscript Draft …
Nephrology In Search of the Mechanism of APOL1 Kidney Disease --Manuscript Draft …