Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid synthesized by a variety of cell types upon appropriate …

Endothelial barrier function is regulated at the cellular level by cytoskeletal-dependent
anchoring and retracting forces. In the present study we have examined the signal …

The binding of neutrophils (polymorphonuclear leukocytes [PMNs]) to endothelial cells
(ECs) presents special requirements in the regulation of intercellular adhesion. ECs that are …

Highly purified human thrombin stimulates the adherence of polymorphonuclear leukocytes
(PMNs) to vascular endothelial cells (EC). When Indium-labeled PMNs were incubated with …

Thrombin, in addition to being a key enzyme in hemostasis, affects a series of endothelial
and leukocyte functions and thus may be involved in the regulation of inflammatory …

Fig. 1. Phospholipase A2 action phospholipids (I) and 1-0-alkyl-2-acyl-glycero-3-
phosphocoline (II). Abbreviations: R1, fatty acid esterified at the sn-1 position, usually …

Cultured human endothelial cells synthesize prostacyclin (PGI2), a potent inhibitor of platelet
function, when stimulated with histamine, bradykinin, or ATP. Paradoxically, we report that …

In postcapillary venules, marginating neutrophils (PMNs) are often seen rolling along the
vessel wall prior to stopping and emigrating. There is substantial evidence in vitro and in …

Two classes of adhesion molecules have well-defined roles in the attachment of
unstimulated polymorphonuclear leukocytes (PMN) to cytokine-treated endothelial cells …

Human endothelial cells in culture produced platelet-activating factor (PAF; 1-O-alkyl-2-
acetyl-sn-glycero-3-phosphocholine) when stimulated with leukotriene C4 or D4 (LTC4 or …