Defining the relative importance of protease-activated receptors (PARs) for thrombin
signaling in mouse endothelial cells is critical for a basic understanding of thrombin …

Murine tumor necrosis factor (mTNF) stimulates production of platelet-activating factor (PAF)
by cultured rat peritoneal macrophages in amounts comparable to those formed during …

Sepsis, defined as the dysregulated immune response to an infection leading to organ
dysfunction, is one of the leading causes of mortality around the globe. Despite the …

The VASCULAR endothelium lining as a monolayer the entire circulatory system does not
represent a passive diffusion barrier but displays the features of a distributed organ (1 to 1.5 …

We compared the effects of phorbol 12-myristate 13-acetate (PMA) and thrombin with those
of nonlytic concentrations of reactive oxygen species (ROS) generated by hypoxanthine …

Cultured rabbit and bovine aortic endothelial cells generated chemotactic activity for mouse
resident peritoneal macrophages, demonstrable in the conditioned medium. This …

Cell-activatingfunctions ofthrombin In addition to cleaving fibrinogen to fibrin, thrombin
exhibits important" cell-activating" functions (Fig. 1; reviewed in ref. 2). First and foremost …

Anaphylaxis is a systemic hypersensitivity reaction that can be life threatening.
Mechanistically, it results from the immune activation and release of a variety of mediators …

Monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of platelet-activating
factor (PAF) in cultured human vascular endothelial cells (HEC). The product was identified …

Human endothelial cells synthesize large amounts of platelet-activating factor (PAF) after 30-
min treatment with recombinant tumor necrosis factor (TNF). Synthesis of PAF peaks at 4-6 …