During inflammation polymorphonuclear cells (PMNs) are exposed to agonistic stimuli
including activated complement, kallikrein, arachidonic acid metabolites, monokines, and …

We have prepared a monoclonal antibody directed against human thrombomodulin. We
used the antibody to measure thrombomodulin molecules in cultured human endothelial …

Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and
thrombin generation are crucial in the physiological response to tissue injury; however, the …

We have analyzed the binding of thrombin, a serine protease with central roles in
hemostasis, to the subendothelial extracellular matrix (ECM) produced by cultured …

Human foreskin microvascular endothelial cells synthesize and release tissue-type
plasminogen activator (t-PA) in similar amounts as do endothelial cells from umbilical cord …

Tumour necrosis factor (TNF) and related cytokines have been found to alter the phenotype
of vascular endothelial cells so as to promote coagulation, inflammation and immunity. We …

Reactive oxygen species do not activate isolated neutrophils, yet in vivo, such oxidants
promote their adhesion to, and subsequent migration through, the vascular wall. We show …

Platelet-activating factor (PAF) is an important mediator of the systemic inflammatory
response. In the case of sepsis, proper activation and function of neutrophils as the first line …

Neutrophil activating factor is a polypeptide cytokine released from stimulated mononuclear
phagocytes and endothelial cells. We found that neutrophil activating factor induced time …

Platelet‐activating factor, an endogenous phospholipid of proinflammatory, hemostatic, and
vasoactive properties, is synthesized by neurons and in injured brain. Platelet‐activating …