Although the causes of necrotizing enterocolitis (NEC) are not well understood, there is
compelling evidence to suggest that the inflammatory mediators play an important role in the …

In a variety of diseases, inflammation causes microvascular leakage and activates thrombin.
Evidence suggests that thrombin increases cytosolic calcium and stimulates human airway …

The protease thrombin is a potent agonist for platelet aggregation, mesenchymal cell
proliferation, and endothelial production of growth factors and adhesion molecules …

The terms" consumption coagulopathy," 1" 3 disseminated intravascular coagulation," 4-6"
generalized intravascular coagulation," 7-8" thrombohemorrhagic phenomenon," 9" …

We examined neutrophil adherence to bovine aortic endothelial cells in 26 patients with
diabetes compared with age-and sex-matched controls. The adherence of chromium 51 …

Recent studies have shown that the synthetic peptides SFL LRN and SFL LRN PND KYEPF
(thrombin receptor-activating peptides (TRAP)) derived from the deduced sequence of the …

The interaction of endothelial cells and polymorphonuclear leukocytes (PMNs, neutrophils)
is a critical determinant of the acute inflammatory response, and mirrors cell–cell interactions …

Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on
cerebrovascular and neural elements. While several investigators have reported attenuation …

Platelet-activating factor (PAF) is a phospholipid mediator of inflammation with a wide range
of biological activities, including the alteration of barrier function of endothelium. A biological …

Thrombin is a well-established promoter of vascu-lar SMC proliferation in vitro. A similar role
has been suggested but not yet proven in vivo. The effect is mediated via selective receptors …