Irinotecan has been used in the treatment of various malignancies for many years. Still, the
knowledge regarding this drug is expanding. The pharmacogenetics of the drug is the …

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal
transducers. They regulate essential cellular processes like proliferation, apoptosis …

Corneal neovascularization is a serious condition that can lead to a profound decline in
vision. The abnormal vessels block light, cause corneal scarring, compromise visual acuity …

Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Chronic myeloid leukemia (CML) is caused by formation of the BCR–ABL1 fusion protein.
Tyrosine kinase inhibitors (TKI) that target BCR–ABL1 are now the standard of care for …

Cancer is the most widely recognized reason for human deaths globally. Conventional
anticancer therapies, including chemotherapy and radiation, are very costly and induce …

Many epithelial and endothelial cells express a cholinergic autocrine loop in which
acetylcholine acts as a growth factor to stimulate cell growth. Cancers derived from these …

Targeted therapy has revolutionized the treatment of poor-prognosis pediatric acute
lymphoblastic leukemia (ALL) with specific genetic abnormalities. It is still being described …

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the
protozoan parasite Trypanosoma brucei. Because drugs in use against HAT are toxic and …

Simple Summary Renal cell carcinoma (RCC) is the sixth most frequently diagnosed cancer
in men and the tenth in women with a rising incidence. The treatment of metastasized RCC …