Curcumin dictates divergent fates for the central salt bridges in amyloid-β40 and amyloid-β42
There are three specific regions in the Amyloid beta (Aβ) peptide sequence where variations
cause enhanced toxicity in Alzheimer's disease: the N-terminus, the central salt bridge, and …
cause enhanced toxicity in Alzheimer's disease: the N-terminus, the central salt bridge, and …
Promoted aggregation of Aβ on lipid bilayers in an open flowing system
A Iida, M Abe, M Nochi, C Soga… - The Journal of …, 2021 - ACS Publications
Self-assembly of amyloid-β (Aβ) peptides in nonequilibrium, flowing conditions is associated
with pathogenesis of Alzheimer's disease. We examined the role of biologically relevant …
with pathogenesis of Alzheimer's disease. We examined the role of biologically relevant …
Gc-protein-derived macrophage activating factor counteracts the neuronal damage induced by oxaliplatin
G Morucci, JJV Branca, M Gulisano… - Anti-Cancer …, 2015 - journals.lww.com
Oxaliplatin-based regimens are effective in metastasized advanced cancers. However, a
major limitation to their widespread use is represented by neurotoxicity that leads to …
major limitation to their widespread use is represented by neurotoxicity that leads to …
Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors
The identification of protein aggregates as biomarkers for neurodegeneration is an area of
interest for disease diagnosis and treatment development. In this work, we present novel …
interest for disease diagnosis and treatment development. In this work, we present novel …
Synthesis of a self organizable curcumin derivative and investigation of its interaction with metals in 100% aqueous media
We report the synthesis of a self organizable and water dispersible bis PEGylated (bis
polyethyleneglycolated) curcumin (1) using an efficient synthetic method. Compound 1 …
polyethyleneglycolated) curcumin (1) using an efficient synthetic method. Compound 1 …
Multifunctionality of Acidulated Serum Albumin on Inhibiting Zn2+-Mediated Amyloid β-Protein Fibrillogenesis and Cytotoxicity
B Xie, X Dong, Y Wang, Y Sun - Langmuir, 2015 - ACS Publications
Fibrillogenesis of amyloid β-proteins (Aβ) mediated by transition-metal ions such as Zn2+ in
neuronal cells plays a causative role in Alzheimer's disease. Hence, it is highly desired to …
neuronal cells plays a causative role in Alzheimer's disease. Hence, it is highly desired to …
The behavior of the adsorption of cytochrome c on lipid monolayers: A study by the Langmuir–Blodgett technique and theoretical analysis
J Li, R Sun, C Hao, G He, L Zhang, J Wang - Biophysical Chemistry, 2015 - Elsevier
Cytochrome c (Cyt c) is an essential component of the inner mitochondrial respiratory chain
because of its function of transferring electrons. The feature is closely related to the …
because of its function of transferring electrons. The feature is closely related to the …
Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
IM Carvalho, PB Coelho, PC Costa, CS Marques… - Neuromolecular …, 2015 - Springer
The adult central nervous system is commonly known to have a very limited regenerative
capacity. The presence of functional stem cells in the brain can therefore be seen as a …
capacity. The presence of functional stem cells in the brain can therefore be seen as a …
Effects of oxaliplatin and oleic acid Gcproteinderived macrophageactivating factor on murine and human microglia
JJV Branca, G Morucci, F Malentacchi… - Journal of …, 2015 - Wiley Online Library
The biological properties and characteristics of microglia in rodents have been widely
described, but little is known about these features in human microglia. Several murine …
described, but little is known about these features in human microglia. Several murine …
Protective effect of trehalose sugar on amyloid-membrane interactions using BLM electrophysiology
Y Xu, CT Filice, Z Leonenko - Biophysical Journal, 2024 - cell.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by dementia and
memory loss in the elderly population. The amyloid-β peptide (Aβ) is one of the main …
memory loss in the elderly population. The amyloid-β peptide (Aβ) is one of the main …