There are three specific regions in the Amyloid beta (Aβ) peptide sequence where variations
cause enhanced toxicity in Alzheimer's disease: the N-terminus, the central salt bridge, and …

Self-assembly of amyloid-β (Aβ) peptides in nonequilibrium, flowing conditions is associated
with pathogenesis of Alzheimer's disease. We examined the role of biologically relevant …

Oxaliplatin-based regimens are effective in metastasized advanced cancers. However, a
major limitation to their widespread use is represented by neurotoxicity that leads to …

The identification of protein aggregates as biomarkers for neurodegeneration is an area of
interest for disease diagnosis and treatment development. In this work, we present novel …

We report the synthesis of a self organizable and water dispersible bis PEGylated (bis
polyethyleneglycolated) curcumin (1) using an efficient synthetic method. Compound 1 …

Fibrillogenesis of amyloid β-proteins (Aβ) mediated by transition-metal ions such as Zn2+ in
neuronal cells plays a causative role in Alzheimer's disease. Hence, it is highly desired to …

Cytochrome c (Cyt c) is an essential component of the inner mitochondrial respiratory chain
because of its function of transferring electrons. The feature is closely related to the …

The adult central nervous system is commonly known to have a very limited regenerative
capacity. The presence of functional stem cells in the brain can therefore be seen as a …

The biological properties and characteristics of microglia in rodents have been widely
described, but little is known about these features in human microglia. Several murine …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by dementia and
memory loss in the elderly population. The amyloid-β peptide (Aβ) is one of the main …