Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic
pathways in prokaryotes and eukaryotes and are involved in many biological processes …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone
H3 N ε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has …

Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …

Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-
dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian …

Silencing of exogenous DNA can make transgene expression very inefficient. Genetic
screens in the model alga Chlamydomonas have demonstrated that transgene silencing can …

Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with
various pharmacological effects. Due to their plethora of biological activities, they have been …

Chronic activation of stress hormones such as glucocorticoids leads to skeletal muscle
wasting in mammals. However, the molecular events that mediate glucocorticoid-induced …

Pancreatic cancer is a highly aggressive cancer, and is primarily treated with gemcitabine,
with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in …

DNA-encoded chemical libraries are increasingly used in pharmaceutical research because
they enable the rapid discovery of synthetic protein ligands. Here we explored whether …