Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Cellular senescence, a characteristic sign of aging, classically refers to permanent cell
proliferation arrest and is a vital contributor to the pathogenesis of cancer and age-related …

How endothelial cells sense and respond to dynamic changes in their biophysical
surroundings as we age is not fully understood. Vascular stiffness is clearly a contributing …

Background Accumulating evidence suggests that autonomic dysfunction and persistent
systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic …

Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Obesity is a worldwide trend that is growing in incidence very fast. Adipose tissue
dysfunction caused by obesity is associated with the generation of oxidative stress. Obesity …

The aging of the global population poses significant scientific challenges. Moreover, the
biological process of aging is the most significant risk factor for most chronic illnesses; …

Aging is the progressive decline of body functions and a number of chronic conditions can
lead to premature aging characterized by frailty, a diseased vasculature, osteoporosis, and …

Endothelial cells are constantly exposed to environmental stress factors that, above a certain
threshold, trigger cellular senescence and apoptosis. The altered vascular function affects …

Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis
and mediate several pathological and physiological processes. Mechanical stresses …