Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

[HTML][HTML] Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system

S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

[HTML][HTML] The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review

H Liao, J Ye, L Gao, Y Liu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Scutellaria baicalensis Georgi., a plant used in traditional Chinese medicine, has multiple
biological activities, including anti-inflammatory, antiviral, antitumor, antioxidant, and …

[HTML][HTML] Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders

MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …

[HTML][HTML] Synopsis of arachidonic acid metabolism: A review

VS Hanna, EAA Hafez - Journal of advanced research, 2018 - Elsevier
Abstract Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double
bonds, is an integral constituent of biological cell membrane, conferring it with fluidity and …

Cannabis and synaptic reprogramming of the developing brain

A Bara, JMN Ferland, G Rompala, H Szutorisz… - Nature Reviews …, 2021 - nature.com
Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

[HTML][HTML] Designer drugs: mechanism of action and adverse effects

D Luethi, ME Liechti - Archives of toxicology, 2020 - Springer
Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

An introduction to the endogenous cannabinoid system

HC Lu, K Mackie - Biological psychiatry, 2016 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Effects of cannabis use on human behavior, including cognition, motivation, and psychosis: a review

ND Volkow, JM Swanson, AE Evins, LE DeLisi… - JAMA …, 2016 - jamanetwork.com
With a political debate about the potential risks and benefits of cannabis use as a backdrop,
the wave of legalization and liberalization initiatives continues to spread. Four states …

[HTML][HTML] Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease

TJ Tracey, FJ Steyn, EJ Wolvetang… - Frontiers in molecular …, 2018 - frontiersin.org
Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …