With a prevalence of 5 800 000 (2% of the entire populace) in 2009 and an estimated yearly
incidence of 550 000, the burden of heart failure (HF) in the United States is tremendous. 1 …

Many uncertainties surround the syndrome of heart failure with preserved ejection fraction
(HFpEF), which was the topic reviewed in an Expert Meeting at the University of Ferrara …

Background: Classification of chronic heart failure (HF) is on the basis of criteria that may not
adequately capture disease heterogeneity. Improved phenotyping may help inform research …

Abstract Sepsis-induced cardiomyopathy (SIC), which is a common morbid condition, occurs
in patients with severe sepsis and septic shock. The clinical characterization of SIC has …

1996 novel principle of evidence-based medicine, the launching of industry-driven clinical
trials, and the emphasis on statistics. Clinical trials introduced a bias in the field of HF by …

OBJECTIVE Phenotypic heterogeneity among patients with type 2 diabetes mellitus (T2DM)
and atherosclerotic cardiovascular disease (ASCVD) is ill defined. We used cluster analysis …

Background Increased arterial stiffness and early wave reflections have been observed in
patients with heart failure and normal ejection fraction (HFNEF). We investigated, whether …

As a leading cause of death and morbidity, heart failure (HF) is responsible for a large
portion of healthcare and disability costs worldwide. Current approaches to define specific …

BACKGROUND: Left ventricular ejection fraction (LVEF) cannot reflect cardiac contractile
function in patients with heart failure and preserved LVEF (HFPEF). LV systolic impairment is …

Aims We tested the hypothesis that, in heart failure with normal ejection fraction (HFNEF),
diastolic dysfunction is accentuated at increasing heart rates, and this contributes to …