Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in
eukaryotes and viruses. They can function by regulating target gene expression, linear RNA …

Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation …

Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …

Background—Cystathionine γ-lyase (CSE) produces H2S via enzymatic conversion of L-
cysteine and plays a critical role in cardiovascular homeostasis. We investigated the effects …

Intercellular junctions mediate adhesion and communication between adjoining cells.
Although formed by different molecules, tight junctions (TJs) and adherens junctions (AJs) …

HMG-CoA reductase inhibitors (statins) have been developed as lipid-lowering drugs and
are well established to reduce morbidity and mortality from coronary artery disease. Here we …

Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel
adipokine, circulating levels of which are raised in inflammatory states. Chemerin shows …

Background—Therapeutic neovascularization may constitute an important strategy to
salvage tissue from critical ischemia. Circulating bone marrow–derived endothelial …

Endothelial cells establish an instructive vascular niche that reconstitutes haematopoietic
stem and progenitor cells (HSPCs) through release of specific paracrine growth factors …

Protein arrays are described for screening of molecular markers and pathway targets in
patient matched human tissue during disease progression. In contrast to previous protein …