Endothelial cell integrins and COX-2: mediators and therapeutic targets of tumor angiogenesis
Vascular integrins are essential regulators and mediators of physiological and pathological
angiogenesis, including tumor angiogenesis. Integrins provide the physical interaction with …
angiogenesis, including tumor angiogenesis. Integrins provide the physical interaction with …
Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure
Background—The hematopoietic cytokine erythropoietin has cytoprotective effects in
endothelial cells in vitro that are mediated through direct activation of the pro-survival Akt …
endothelial cells in vitro that are mediated through direct activation of the pro-survival Akt …
[HTML][HTML] Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism
K Breitschopf, AM Zeiher, S Dimmeler - FEBS letters, 2001 - Elsevier
Advanced aging may contribute to impairment of angiogenesis and development of vascular
diseases. Telomerase was shown to delay endothelial cell (EC) senescence. Therefore, we …
diseases. Telomerase was shown to delay endothelial cell (EC) senescence. Therefore, we …
Hepatopulmonary syndrome: update on pathogenesis and clinical features
J Zhang, MB Fallon - Nature reviews Gastroenterology & hepatology, 2012 - nature.com
Hepatopulmonary syndrome (HPS) is a serious vascular complication of liver disease that
occurs in 5–32% of patients with cirrhosis. The presence of HPS markedly increases …
occurs in 5–32% of patients with cirrhosis. The presence of HPS markedly increases …
Tumour angiogenesis: its mechanism and therapeutic implications in malignant gliomas
MLH Wong, A Prawira, AH Kaye, CM Hovens - Journal of Clinical …, 2009 - Elsevier
Angiogenesis is a key event in the progression of malignant gliomas. The presence of
microvascular proliferation leads to the histological diagnosis of glioblastoma multiforme …
microvascular proliferation leads to the histological diagnosis of glioblastoma multiforme …
Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo
Y Okamoto, W Sonoyama, M Ono, K Akiyama… - Journal of …, 2009 - Elsevier
Statin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is known to promote
bone formation. However, it is not clear whether statin affects the differentiation of pulp cells …
bone formation. However, it is not clear whether statin affects the differentiation of pulp cells …
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics
BACKGROUND: The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt
murine thymoma viral oncogene homolog/mechanistic target of rapamycin …
murine thymoma viral oncogene homolog/mechanistic target of rapamycin …
Dephosphorylation of endothelial nitric oxide synthase contributes to the anti‐angiogenic effects of endostatin
C Urbich, A Reissner, E Chavakis… - The FASEB …, 2002 - Wiley Online Library
Endostatin is an anti‐angiogenic factor that inhibits endothelial cell (EC) migration and
induces EC apoptosis. Because nitric oxide (NO) plays a key role in vascular endothelial …
induces EC apoptosis. Because nitric oxide (NO) plays a key role in vascular endothelial …
Green tea catechins inhibit VEGF‐induced angiogenesis in vitro through suppression of VE‐cadherin phosphorylation and inactivation of Akt molecule
Studies have indicated that the consumption of green tea is associated with a reduced risk of
developing certain forms of cancer and angiogenesis. The mechanism of inhibition of …
developing certain forms of cancer and angiogenesis. The mechanism of inhibition of …
Laminar shear stress upregulates integrin expression: role in endothelial cell adhesion and apoptosis
C Urbich, DH Walter, AM Zeiher, S Dimmeler - Circulation research, 2000 - Am Heart Assoc
Laminar shear stress exerts important effects on endothelial cell (EC) function and inhibits
apoptosis of ECs induced by various stimuli. The mechanism by which hemodynamic forces …
apoptosis of ECs induced by various stimuli. The mechanism by which hemodynamic forces …