Endothelial cell integrins and COX-2: mediators and therapeutic targets of tumor angiogenesis

C Rüegg, O Dormond, A Mariotti - … et Biophysica Acta (BBA)-Reviews on …, 2004 - Elsevier
Vascular integrins are essential regulators and mediators of physiological and pathological
angiogenesis, including tumor angiogenesis. Integrins provide the physical interaction with …

Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure

FH Bahlmann, R Song, SM Boehm, M Mengel… - Circulation, 2004 - Am Heart Assoc
Background—The hematopoietic cytokine erythropoietin has cytoprotective effects in
endothelial cells in vitro that are mediated through direct activation of the pro-survival Akt …

[HTML][HTML] Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism

K Breitschopf, AM Zeiher, S Dimmeler - FEBS letters, 2001 - Elsevier
Advanced aging may contribute to impairment of angiogenesis and development of vascular
diseases. Telomerase was shown to delay endothelial cell (EC) senescence. Therefore, we …

Hepatopulmonary syndrome: update on pathogenesis and clinical features

J Zhang, MB Fallon - Nature reviews Gastroenterology & hepatology, 2012 - nature.com
Hepatopulmonary syndrome (HPS) is a serious vascular complication of liver disease that
occurs in 5–32% of patients with cirrhosis. The presence of HPS markedly increases …

Tumour angiogenesis: its mechanism and therapeutic implications in malignant gliomas

MLH Wong, A Prawira, AH Kaye, CM Hovens - Journal of Clinical …, 2009 - Elsevier
Angiogenesis is a key event in the progression of malignant gliomas. The presence of
microvascular proliferation leads to the histological diagnosis of glioblastoma multiforme …

Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo

Y Okamoto, W Sonoyama, M Ono, K Akiyama… - Journal of …, 2009 - Elsevier
Statin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is known to promote
bone formation. However, it is not clear whether statin affects the differentiation of pulp cells …

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics

A Italiano, CL Chen, R Thomas, M Breen, F Bonnet… - Cancer, 2012 - Wiley Online Library
BACKGROUND: The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt
murine thymoma viral oncogene homolog/mechanistic target of rapamycin …

Dephosphorylation of endothelial nitric oxide synthase contributes to the anti‐angiogenic effects of endostatin

C Urbich, A Reissner, E Chavakis… - The FASEB …, 2002 - Wiley Online Library
Endostatin is an anti‐angiogenic factor that inhibits endothelial cell (EC) migration and
induces EC apoptosis. Because nitric oxide (NO) plays a key role in vascular endothelial …

Green tea catechins inhibit VEGF‐induced angiogenesis in vitro through suppression of VE‐cadherin phosphorylation and inactivation of Akt molecule

FY Tang, N Nguyen, M Meydani - International Journal of …, 2003 - Wiley Online Library
Studies have indicated that the consumption of green tea is associated with a reduced risk of
developing certain forms of cancer and angiogenesis. The mechanism of inhibition of …

Laminar shear stress upregulates integrin expression: role in endothelial cell adhesion and apoptosis

C Urbich, DH Walter, AM Zeiher, S Dimmeler - Circulation research, 2000 - Am Heart Assoc
Laminar shear stress exerts important effects on endothelial cell (EC) function and inhibits
apoptosis of ECs induced by various stimuli. The mechanism by which hemodynamic forces …