Mechanisms of diabetic foot ulceration: A review

H Deng, B Li, Q Shen, C Zhang, L Kuang… - Journal of …, 2023 - Wiley Online Library
Diabetic foot ulcers (DFUs) are associated with complex pathogenic factors and are
considered a serious complication of diabetes. The potential mechanisms underlying DFUs …

Wnt Signaling in vascular eye diseases

Z Wang, CH Liu, S Huang, J Chen - Progress in retinal and eye research, 2019 - Elsevier
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …

Exosomal OTULIN from M2 macrophages promotes the recovery of spinal cord injuries via stimulating Wnt/β-catenin pathway-mediated vascular regeneration

Z Luo, W Peng, Y Xu, Y Xie, Y Liu, H Lu, Y Cao, J Hu - Acta biomaterialia, 2021 - Elsevier
Vascularization following spinal cord injury (SCI) provides trophic support for rebuilding up
and maintaining the homeostasis of neuronal networks, and the promotion of angiogenesis …

The effect of silicate ions on proliferation, osteogenic differentiation and cell signalling pathways (WNT and SHH) of bone marrow stromal cells

P Han, C Wu, Y Xiao - Biomaterials Science, 2013 - pubs.rsc.org
Silicon (Si) is a trace element, which plays an important role in human bone growth. Si has
been incorporated into biomaterials for bone regeneration in order to improve their …

Role of Wnt/β-catenin signaling in drug resistance of pancreatic cancer

J Cui, W Jiang, S Wang, L Wang… - Current pharmaceutical …, 2012 - ingentaconnect.com
Pancreatic cancer is characterized by its intrinsic resistance to cytotoxic agents. But the
underlying molecular mechanism is unclear. Studies demonstrate that angiogenesis …

High levels of pigment epithelium–derived factor in diabetes impair wound healing through suppression of Wnt signaling

W Qi, C Yang, Z Dai, D Che, J Feng, Y Mao… - Diabetes, 2015 - Am Diabetes Assoc
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular
complication of diabetes. The current study revealed that plasma levels of pigment …

Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure–function continuum with intrinsic disorder-based proteoforms

AV Fonin, AL Darling, IM Kuznetsova… - Cellular and Molecular …, 2019 - Springer
GPCR–G protein signaling system recognizes a multitude of extracellular ligands and
triggers a variety of intracellular signaling cascades in response. In humans, this system …

Regulatory mechanisms and regeneration strategies of the soft–hard tissue interface in the human periodontium

G Dang, Y Wei, Q Wan, J Gu, K Wang, M Wan… - …, 2024 - Wiley Online Library
The soft‐hard tissue interface of the human periodontium is responsible for periodontal
homeostasis and is essential for normal oral activities. This soft‐hard tissue interface is …

[HTML][HTML] Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin …

EEM Chen, W Zhang, CCY Ye, X Gao, LLJ Jiang… - Cell Death & …, 2017 - nature.com
Abstract Sirtuin 7 (SIRT7) is a NAD+-dependent deacetylase in the sirtuin family. In a
previous study, human bone marrow mesenchymal stem cells (hBMSCs) with reduced …

[HTML][HTML] Systems biology approach to identify alterations in the stem cell reservoir of subcutaneous adipose tissue in a rat model of diabetes: effects on differentiation …

R Ferrer-Lorente, MT Bejar, M Tous, G Vilahur… - Diabetologia, 2014 - Springer
Aims/hypothesis Autologous progenitor cells represent a promising option for regenerative
cell-based therapies. Nevertheless, it has been shown that ageing and cardiovascular risk …