Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …

Highlights•Endolysosomal organelles are dynamically distributed throughout the
cytoplasm.•Movement of endolysosomal organelles depends on coupling to microtubule …

Long-distance intracellular delivery is driven by kinesin and dynein motor proteins that ferry
cargoes along microtubule tracks [1, 2]. Current models postulate that directional trafficking …

Nanomanufacturing, the commercially scalable and economically sustainable mass
production of nanoscale materials and devices, represents the tangible outcome of the …

In the last two decades, considerable progress has been made in the field of molecular
biology, which has enabled a molecular-level understanding of a number of interesting …

Intracellular transport is fundamental for neuronal morphogenesis, function and survival.
Many proteins are selectively transported to either axons or dendrites. In addition, some …

Various molecular cell biology and molecular genetic approaches have indicated significant
roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that …

Summary Cytoplasmic dynein, the 1.2 MDa motor driving minus-end-directed motility, has
been reported to move processively along microtubules, but its mechanism of motility …

Oocyte maturation is a long process during which oocytes acquire their intrinsic ability to
support the subsequent stages of development in a stepwise manner, ultimately reaching …

Here we report the crystal structure of the 380-kDa motor domain of Dictyostelium
cytoplasmic dynein at 2.8 Aresolution. This atomic structure shows details of functional units …