Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

Osteoarthritis is a degenerative disorder that can severely affect joints, and new treatment
strategies are urgently needed. Administration of mesenchymal stem cell (MSC)‐derived …

Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of
pathologic changes involves all the tissues forming the joint; already, at an early stage, it has …

Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that is the most
common joint disease worldwide. Mesenchymal stem cells (MSCs) have been the most …

Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major
research efforts. Different tissues and cell-types within the joint contribute to disease …

Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …

Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-
articular bone, but there is increasing recognition that OA affects all of the joint tissues …

Cytokines activate or inhibit immune cell behavior and are thus integral to all immune
responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream …

Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …