Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Post-translational modifications of connexins play an important role in the regulation of gap
junction and hemichannel permeability. The prerequisite for the formation of functional gap …

Connexin hemichannels (connexons) are building blocks of gap junctions but also function
as free unapposed channels, which has become an active field of research. Defining …

Vertebrate cells that express connexins likely express connexin hemichannels (Cx HCs) at
their surface. In diverse cell types, surface Cx HCs can open to serve as a diffusional …

Objective—To determine whether S-nitrosylation of connexins (Cxs) modulates gap junction
communication between endothelium and smooth muscle. Methods and Results …

Gap junctions are comprised of connexins that form cell-to-cell channels which couple
neighboring cells to accommodate the exchange of information. The need for …

Connexin-assembled gap junctions (GJs) and hemichannels coordinate intercellular
signaling processes. Although the regulation of connexins in GJs has been well …

Posttranslational modification is a common cellular process that is used by cells to ensure a
particular protein function. This can happen in a variety of ways, eg, from the addition of …

NO is generated within cells and frequently must be transferred to responsive neighboring
cells, as occurs in the endothelium-dependent relaxation of smooth muscle cells observed in …

The normal function and survival of cells in the avascular lens is facilitated by intercellular
communication through an extensive network of gap junctions formed predominantly by …