Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

DNA methylation: conducting the orchestra from exposure to phenotype?

FAD Leenen, CP Muller, JD Turner - Clinical epigenetics, 2016 - Springer
Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …

Epigenetic and neurological impairments associated with early life exposure to persistent organic pollutants

N Grova, H Schroeder, JL Olivier… - International journal of …, 2019 - Wiley Online Library
The incidence of neurodevelopmental and neurodegenerative diseases worldwide has
dramatically increased over the last decades. Although the aetiology remains uncertain …

Using all our genomes: Blood‐based liquid biopsies for the early detection of cancer

E Adams, GD Sepich‐Poore, S Miller‐Montgomery… - View, 2022 - Wiley Online Library
The pursuit of highly sensitive and specific cancer diagnostics based on cell‐free nucleic
acids isolated from minimally invasive liquid biopsies has been an area of intense research …

[HTML][HTML] Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation

R Gondalia, A Baldassari, KM Holliday… - Environment …, 2019 - Elsevier
Background DNA methylation (DNAm) may contribute to processes that underlie
associations between air pollution and poor health. Therefore, our objective was to evaluate …

The role of the microenvironment in controlling the fate of bioprinted stem cells

LN West-Livingston, J Park, SJ Lee, A Atala… - Chemical …, 2020 - ACS Publications
The field of tissue engineering and regenerative medicine has made numerous advances in
recent years in the arena of fabricating multifunctional, three-dimensional (3D) tissue …

A review of the bioactive properties of Mongolian plants, with a focus on their potential as natural food preservatives

M Burenjargal, T Narangerel, T Batmunkh… - Food Science & …, 2023 - Wiley Online Library
Consumers have recently preferred food that is easy to make and of excellent quality, as
well as food that is safe, natural, and minimally processed, but has a longer shelf life. Food …

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control

B Oriol-Tordera, M Berdasco, A Llano, B Mothe… - PLoS …, 2020 - journals.plos.org
GWAS, immune analyses and biomarker screenings have identified host factors associated
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …

[HTML][HTML] Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-L1 treatment

K Laubach, T Turan, R Mathew… - Cancer Drug …, 2023 - ncbi.nlm.nih.gov
The development of immune checkpoint blockade (ICB) therapies has been instrumental in
advancing the field of immunotherapy. Despite the prominence of these treatments, many …

DNA Methylation signature of aging: Potential impact on the pathogenesis of parkinson's disease

V Yazar, VL Dawson, TM Dawson… - Journal of Parkinson's …, 2023 - journals.sagepub.com
Regulation of gene expression by epigenetic modifications means lasting and heritable
changes in the function of genes without alterations in the DNA sequence. Of all epigenetic …