Modulation by adenosine of both muscarinic M1‐facilitation and M2‐inhibition of [3H]‐acetylcholine release from the rat motor nerve terminals

L Oliveira, MA Timóteo… - European Journal of …, 2002 - Wiley Online Library
The crosstalk between adenosine and muscarinic autoreceptors regulating evoked [3H]‐
acetylcholine ([3H]‐ACh) release was investigated on rat phrenic nerve‐hemidiaphragm …

Role of adenosine signaling in penile erection and erectile disorders

PV Phatarpekar, J Wen, Y Xia - The journal of sexual medicine, 2010 - academic.oup.com
Introduction Penile erection is a hemodynamic process, which results from increased flow
and retention of blood in the penile organ due to the relaxation of smooth muscle cells …

Adenosine signaling in reserpine-induced depression in rats

TR Minor, TC Hanff - Behavioural Brain Research, 2015 - Elsevier
A single, 6 mg/kg intraperitoneal injection of reserpine increased floating time during forced
swim testing 24 h after administration in rats in five experiments. Although such behavioral …

Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice

BM Fontinha, JM Delgado-Garcia, N Madronal… - …, 2009 - nature.com
Previous in vitro studies have characterized the electrophysiological and molecular
signaling pathways of adenosine tonic modulation on long-lasting synaptic plasticity events …

Improved spatial recognition memory in mice lacking adenosine A2A receptors

JH Wang, YY Ma, M van den Buuse - Experimental neurology, 2006 - Elsevier
Adenosine receptors play an important role in learning and memory as their antagonists
have been found to facilitate learning and memory in various tasks in rodents. However, few …

Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor‐mediated inhibition of corticostriatal glutamatergic transmission

SG Ferreira, FQ Gonçalves, JM Marques… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Both cannabinoid CB 1 and adenosine A2A receptors (CB1
receptors and A2A receptors) control synaptic transmission at corticostriatal synapses, with …

[HTML][HTML] Modulation of brain-derived neurotrophic factor (BDNF) actions in the nervous system by adenosine A2A receptors and the role of lipid rafts

AM Sebastião, N Assaife-Lopes, MJ Diógenes… - … et Biophysica Acta (BBA …, 2011 - Elsevier
In this paper we review some novel aspects related to the way adenosine A2A receptors
(A2AR) modulate the action of BDNF or its high-affinity receptors, the TrkB receptors, on …

Modulators of nucleoside metabolism in the therapy of brain diseases

D Boison - Current topics in medicinal chemistry, 2011 - ingentaconnect.com
Nucleoside receptors are known to be important targets for a variety of brain diseases.
However, the therapeutic modulation of their endogenous agonists by inhibitors of …

Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection

AM Sebastião, JA Ribeiro - British journal of pharmacology, 2009 - Wiley Online Library
G protein coupled receptors and tropomyosin‐related kinase (Trk) receptors have distinct
structure and transducing mechanisms; therefore, cross‐talk among them was unexpected …

The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in …

D Blum, D Gall, MC Galas, P d'Alcantara… - Journal of …, 2002 - Soc Neuroscience
Huntington's disease is a genetic neurodegenerative disorder characterized clinically by
both motor and cognitive impairments and striatal lesions. At present, there are no …