Mortality and morbidity were examined in 117 laboratory-maintained rhesus monkeys
studied over approximately 25 years (8 dietary-restricted [DR] and 109 ad libitum-fed [AL] …

Background and Purpose Diabetes is a major risk factor for morbidity and mortality from
cardiovascular disease. However, the role of the primary metabolic abnormality of diabetes …

We studied the association between retinopathy and glucose metabolism in a population-
based study of elderly men and women. Glucose metabolism was assessed by serum …

Background: Rhesus monkeys have a high prevalence of obesity and spontaneous type 2
diabetes mellitus after the age of 10 years. These monkeys go through a defined, sequential …

Although it is difficult to distinguish between the relative effects of insulin resistance and
hyperinsulinemia, insulin resistance is clearly associated with significantly increased …

Transplantation of unpurified islets into the liver, unlike that of purified islets, causes portal
hypertension and coagulopathy. The aim of this project was to determine the most suitable …

Impaired reactivity of the resistance vasculature may contribute to the development of
diabetic microangiopathy by altering microvascular haemodynamics. This study investigates …

Aim: This study was undertaken to test the hypothesis that insulin treatment has unexpected
pro-atherogenic effects at the cellular level, namely, proliferative activity and intracellular …

The cross-sectional study was conducted on 200 newly diagnosed diabetic patients to
assess the prevalence of diabetic retinopathy and to evaluate its relationship with potential …

The prevalence of hypertension and atherosclerosis among subjects with hyperinsulinemia
supports the premise of a direct metabolic link between insulin and angiotensin II at the …