Fibromyalgia (FM) is a syndrome of unknown aetiology characterised by chronic pain,
fatigue, and disturbed sleep. This review presents and summarises the 2020 literature on …

Fibromyalgia (FM) is a chronic pain sensitivity syndrome characterized by diffuse
musculoskeletal pain and many other systemic manifestations. Low-dose naltrexone (LDN) …

Objectives: While opioids temporarily alleviate pain, the overshoot of balancing pain drivers
may increase pain, leading to opioid induced hyperalgesia (OIH). Our goal was to find out …

Background Low-dose naltrexone is used to treat fibromyalgia despite minimal evidence for
its efficacy. This trial aimed to investigate whether 12-week treatment with 6 mg low-dose …

Objectives: First, to examine if LDN is associated with analgesic efficacy compared with
control in the treatment of patients with FM. Second, to ascertain the analgesic efficacy of …

Background Low-dose naltrexone (LDN) is used widely as an off-label treatment for pain
despite limited evidence for its effectiveness. A few small trials with a high risk of bias have …

Introduction There is evidence that low-dose naltrexone (LDN;< 5.0 mg/day) reduces pain
and improves the quality of life of people with fibromyalgia syndrome (FMS). However, no …

Chronic pain conditions create major financial and emotional burdens that can be
devastating for individuals and society. One primary source of pain is arthritis, a common …

Background Low dose naltrexone (LDN) is used off-label by many individuals with
fibromyalgia to help manage their pain. There is no current systematic literature review …

Purpose Despite the availability of a wide variety of analgesics, many patients with chronic
pain often experience suboptimal pain relief in part related to the absence of any medication …