[HTML][HTML] Insulin resistance as the molecular link between diabetes and Alzheimer's disease
MMI Abdalla - World Journal of Diabetes, 2024 - pmc.ncbi.nlm.nih.gov
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that
have seen a rising prevalence worldwide. Recent studies have indicated a possible link …
have seen a rising prevalence worldwide. Recent studies have indicated a possible link …
Structural, kinetic, and thermodynamic aspects of insulin aggregation
Given the significance of protein aggregation in proteinopathies and the development of
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …
Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1–42 aggregates
K Zhaliazka, M Matveyenka, D Kurouski - The FEBS journal, 2023 - Wiley Online Library
Abrupt aggregation of amyloid β1‐42 (Aβ) peptide is a hallmark of Alzheimer's disease (AD),
a severe pathology that affects more than 44 million people worldwide. A growing body of …
a severe pathology that affects more than 44 million people worldwide. A growing body of …
The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine
Progressive degeneration of dopaminergic neurons in the midbrain, hypothalamus, and
thalamus is a hallmark of Parkinson's disease (PD). Neuronal death is linked to the abrupt …
thalamus is a hallmark of Parkinson's disease (PD). Neuronal death is linked to the abrupt …
Fatty acids reverse the supramolecular chirality of insulin fibrils
Long-chain unsaturated and polyunsaturated fatty acids (LCUFAs and LCPUFAs,
respectively) are the essential components of phospholipids and sphingolipids, major …
respectively) are the essential components of phospholipids and sphingolipids, major …
Role of saturation and length of fatty acids of phosphatidylserine in the aggregation of transthyretin
The progressive accumulation of transthyretin (TTR), a small protein that transports
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
Phospholipids and Cholesterol Determine Molecular Mechanisms of Cytotoxicity of α-Synuclein Oligomers and Fibrils
K Zhaliazka, A Ali, D Kurouski - ACS Chemical Neuroscience, 2024 - ACS Publications
Progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta,
hypothalamus, and thalamus is a hallmark of Parkinson's disease. Neuronal death is linked …
hypothalamus, and thalamus is a hallmark of Parkinson's disease. Neuronal death is linked …
Secondary structure and toxicity of transthyretin fibrils can be altered by unsaturated fatty acids
Transthyretin amyloidosis is a severe pathology characterized by the progressive
accumulation of transthyretin (TTR) in various organs and tissues. This highly conserved …
accumulation of transthyretin (TTR) in various organs and tissues. This highly conserved …
Saturation of fatty acids in phosphatidic acid uniquely alters transthyretin stability changing morphology and toxicity of amyloid fibrils
Transthyretin (TTR) is a small, β-sheet-rich tetrameric protein that transports thyroid hormone
thyroxine and retinol. Phospholipids, including phosphatidic acid (PA), can uniquely alter the …
thyroxine and retinol. Phospholipids, including phosphatidic acid (PA), can uniquely alter the …
[HTML][HTML] Unsaturated fatty acids uniquely alter aggregation rate of α-synuclein and insulin and change the secondary structure and toxicity of amyloid aggregates …
M Matveyenka, K Zhaliazka… - FASEB journal: official …, 2023 - ncbi.nlm.nih.gov
Docosahexaenoic (DHA) and arachidonic acids (ARA) are omega-3 and omega-6 long-
chain polyunsaturated fatty acids (LCPUFAs). These molecules constitute a substantial …
chain polyunsaturated fatty acids (LCPUFAs). These molecules constitute a substantial …