Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …

Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

With immunotherapy enjoying a rapid resurgence based on the achievement of durable
remissions in some patients with agents that derepress immune function, commonly referred …

Mammalian target of rapamycin (mTOR) is an atypical protein kinase that controls growth
and metabolism in response to nutrients, growth factors and cellular energy levels, and it is …

Increased glucose metabolism and reprogramming toward aerobic glycolysis are a hallmark
of cancer cells, meeting their metabolic needs for sustained cell proliferation. Metabolic …

Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC
kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1. The liver …

Lysosome is a key subcellular organelle in the execution of the autophagic process and at
present little is known whether lysosomal function is controlled in the process of autophagy …

Alterations of signal transduction pathways leading to uncontrolled cellular proliferation,
survival, invasion, and metastases are hallmarks of the carcinogenic process. The …