Lipoprotein (a): resurrected by genetics

F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

The different facets of dyslipidemia and hypertension in atherosclerosis

J Hurtubise, K McLellan, K Durr, O Onasanya… - Current atherosclerosis …, 2016 - Springer
Atherosclerosis is the narrowing of arteries due to the accumulation of macrophages
overloaded with lipids resulting in foam cell formation, and these events occur preferentially …

C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients

S Tsimikas, JT Willerson, PM Ridker - Journal of the American College of …, 2006 - jacc.org
Several emerging plasma biomarkers may ultimately prove useful in risk stratification and
prognosis of cardiovascular disease. The clinical utility of these biomarkers will depend on …

Lipoprotein (a) an elusive cardiovascular risk factor

L Berglund, R Ramakrishnan - Arteriosclerosis, thrombosis, and …, 2004 - Am Heart Assoc
Lipoprotein (a)[Lp (a)], is present only in humans, Old World nonhuman primates, and the
European hedgehog. Lp (a) has many properties in common with low-density lipoprotein …

Lipoprotein (a) further increases the risk of coronary events in men with high global cardiovascular risk

A von Eckardstein, H Schulte, P Cullen… - Journal of the American …, 2001 - jacc.org
OBJECTIVES This prospective population study was conducted to assess the role of
elevated lipoprotein (a)[Lp (a)] as a coronary risk factor. BACKGROUND The role of elevated …

Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective …

S Tsimikas, S Kiechl, J Willeit, M Mayr, ER Miller… - Journal of the American …, 2006 - jacc.org
Objectives: The purpose of this work was to determine the predictive value of oxidized
phospholipids (OxPLs) present on apolipoprotein B-100 particles (apoB) in carotid and …

Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein (a) isoform size, and cardiovascular risk factors: results from …

S Tsimikas, P Clopton, ES Brilakis, SM Marcovina… - Circulation, 2009 - Am Heart Assoc
Background—Elevated levels of oxidized phospholipids (OxPLs) on apolipoprotein B-100
particles (OxPL/apoB) are associated with cardiovascular disease and predict new …

Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice

E Merki, M Graham, A Taleb, G Leibundgut… - Journal of the American …, 2011 - jacc.org
Objectives: This study sought to assess whether an antisense oligonucleotide (ASO)
directed to apolipoprotein (a)[apo (a)] reduces apo (a) and lipoprotein (a)[Lp (a)] levels in …

The metabolism of lipoprotein (a): an ever-evolving story

G Reyes-Soffer, HN Ginsberg, R Ramakrishnan - Journal of lipid research, 2017 - ASBMB
Lipoprotein (a)[Lp (a)] is characterized by apolipoprotein (a)[apo (a)] covalently bound to
apolipoprotein B 100. It was described in human plasma by Berg et al. in 1963 and the gene …