[HTML][HTML] NAC, NAC, Knockin'on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells

B Kalyanaraman - Redox Biology, 2022 - Elsevier
N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

L Qian, Y Zhu, C Deng, Z Liang, J Chen… - … and Targeted Therapy, 2024 - nature.com
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Osteocyte mitochondria inhibit tumor development via STING-dependent antitumor immunity

H Zhou, W Zhang, H Li, F Xu, E Yinwang, Y Xue… - Science …, 2024 - science.org
Bone is one of the most common sites of tumor metastases. During the last step of bone
metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by …

Mitochondrial transfer between cell crosstalk-an emerging role in mitochondrial quality control

Y Liu, T Fu, G Li, B Li, G Luo, N Li, Q Geng - Ageing Research Reviews, 2023 - Elsevier
Intercellular signaling and component conduction are essential for multicellular organisms'
homeostasis, and mitochondrial transcellular transport is a key example of such cellular …

Exploring the mystery of tumor metabolism: Warburg effect and mitochondrial metabolism fighting side by side

Y Yu, Y Jiang, C Glandorff, M Sun - Cellular Signalling, 2024 - Elsevier
The metabolic reconfiguration of tumor cells constitutes a pivotal aspect of tumor
proliferation and advancement. This study delves into two primary facets of tumor …

Therapeutic effects of mesenchymal stromal cells require mitochondrial transfer and quality control

AN Mukkala, M Jerkic, Z Khan, K Szaszi… - International Journal of …, 2023 - mdpi.com
Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs)
have been the focus of intense preclinical research and clinical implementation for decades …

Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy

F Guan, X Wu, J Zhou, Y Lin, Y He, C Fan… - Journal of Experimental …, 2024 - Springer
A century ago, the Warburg effect was first proposed, revealing that cancer cells
predominantly rely on glycolysis during the process of tumorigenesis, even in the presence …

Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential

Y Liu, L Wang, J Ai, K Li - Stem Cell Reviews and Reports, 2024 - Springer
Mesenchymal stem cells (MSCs) have become popular tool cells in the field of
transformation and regenerative medicine due to their function of cell rescue and cell …

Human Dental Pulp Stem Cells Are Subjected to Metabolic Reprogramming and Repressed Proliferation and Migration by the Sympathetic Nervous System via α1B …

C Yang, Q Gao, N Xu, K Yang, Z Bian - Journal of Endodontics, 2023 - Elsevier
Introduction Human dental pulp stem cells (hDPSCs) reside in specialized
microenvironments in the dental pulp, termed “niches,” which are composed of diverse …

BaoShenTongLuo formula protects against podocyte injury by regulating AMPK-mediated mitochondrial biogenesis in diabetic kidney disease

Y Guo, M Wang, Y Liu, Y Pang, L Tian, J Zhao, M Liu… - Chinese Medicine, 2023 - Springer
Background Mitochondrial dysfunction is considered to be an important contributor in
podocyte injury under diabetic conditions. The BaoShenTongLuo (BSTL) formula has been …