Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

There are a variety of medical conditions associated with chronic sinonasal inflammation,
including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided …

Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …

Background Protecting the upper airway from microbial infection is an important function of
the immune system. Proper detection of these pathogens is paramount for sinonasal …

Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local
inflammation of the upper airways and is historically divided into 2 main phenotypes: CRS …

TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …

Since the discovery of TMEM16A (anoctamin 1, ANO1) as Ca 2+-activated Cl− channel, the
protein was found to serve different physiological functions, depending on the type of tissue …

Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) chloride channel, leading to defective apical chloride transport. Patients …

Aflatoxins are mycotoxins secreted by Aspergillus flavus, which can colonize the respiratory
tract and cause fungal rhinosinusitis or bronchopulmonary aspergillosis. A. flavus is the …

Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory
capacity linked to vagal neurons and immune cells. How PNECs sense and respond to …