The inositol trisphosphate/calcium signaling pathway in health and disease
MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
Chronic rhinosinusitis pathogenesis
WW Stevens, RJ Lee, RP Schleimer… - Journal of Allergy and …, 2015 - Elsevier
There are a variety of medical conditions associated with chronic sinonasal inflammation,
including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided …
including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided …
[HTML][HTML] Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …
Mechanisms and pathogenesis of chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local
inflammation of the upper airways and is historically divided into 2 main phenotypes: CRS …
inflammation of the upper airways and is historically divided into 2 main phenotypes: CRS …
[HTML][HTML] Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction
W Yu, TO Moninger, MV Rector, DA Stoltz, MJ Welsh - Developmental cell, 2022 - cell.com
Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory
capacity linked to vagal neurons and immune cells. How PNECs sense and respond to …
capacity linked to vagal neurons and immune cells. How PNECs sense and respond to …
New insights into upper airway innate immunity
BM Hariri, NA Cohen - American Journal of Rhinology & …, 2016 - journals.sagepub.com
Background Protecting the upper airway from microbial infection is an important function of
the immune system. Proper detection of these pathogens is paramount for sinonasal …
the immune system. Proper detection of these pathogens is paramount for sinonasal …
Modulating Ca2+ signals: a common theme for TMEM16, Ist2, and TMC
K Kunzelmann, I Cabrita, P Wanitchakool… - … -European Journal of …, 2016 - Springer
Since the discovery of TMEM16A (anoctamin 1, ANO1) as Ca 2+-activated Cl− channel, the
protein was found to serve different physiological functions, depending on the type of tissue …
protein was found to serve different physiological functions, depending on the type of tissue …
[HTML][HTML] CLCA1 regulates airway mucus production and ion secretion through TMEM16A
R Centeio, J Ousingsawat, R Schreiber… - International journal of …, 2021 - mdpi.com
TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …
Synergy of cAMP and calcium signaling pathways in CFTR regulation
Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) chloride channel, leading to defective apical chloride transport. Patients …
regulator (CFTR) chloride channel, leading to defective apical chloride transport. Patients …
[HTML][HTML] Fungal aflatoxins reduce respiratory mucosal ciliary function
Aflatoxins are mycotoxins secreted by Aspergillus flavus, which can colonize the respiratory
tract and cause fungal rhinosinusitis or bronchopulmonary aspergillosis. A. flavus is the …
tract and cause fungal rhinosinusitis or bronchopulmonary aspergillosis. A. flavus is the …