[HTML][HTML] Blood–Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies
AE Alkhalifa, NF Al-Ghraiybah, J Odum… - International Journal of …, 2023 - mdpi.com
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
Alzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches
A Gholami - Neuroscience Letters, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurological disorder that affects the central
nervous system (CNS), leading to memory and cognitive decline. In AD, the brain …
nervous system (CNS), leading to memory and cognitive decline. In AD, the brain …
The role of microglia heterogeneity in synaptic plasticity and brain disorders: Will sequencing shed light on the discovery of new therapeutic targets?
Y You, Z Chen, WW Hu - Pharmacology & Therapeutics, 2024 - Elsevier
Microglia play a crucial role in interacting with neuronal synapses and modulating synaptic
plasticity. This function is particularly significant during postnatal development, as microglia …
plasticity. This function is particularly significant during postnatal development, as microglia …
[HTML][HTML] Pegylated Gold Nanoparticles Conjugated with siRNA: Complexes Formation and Cytotoxicity
E Okła, P Białecki, M Kędzierska… - International Journal of …, 2023 - mdpi.com
Drug delivery systems such as dendrimers, liposomes, polymers or gold/silver nanoparticles
could be used to advance modern medicine. One significant pharmacological problem is …
could be used to advance modern medicine. One significant pharmacological problem is …
[HTML][HTML] Association of ApoE gene polymorphisms with serum lipid levels and the risk of type 2 diabetes mellitus in the Chinese Han population of central China
Y Zeng, S Wen, L Huan, L Xiong, B Zhong, P Wang - PeerJ, 2023 - peerj.com
Background Apolipoprotein E (ApoE) is involved in lipid transformation and metabolism.
Although some studies have examined the association between ApoE polymorphisms and …
Although some studies have examined the association between ApoE polymorphisms and …
[HTML][HTML] Apolipoprotein E (APOE) haplotypes in healthy subjects from worldwide macroareas: A population genetics perspective for cardiovascular disease …
Human APOE is a 299-amino acid long protein expressed and secreted in several tissues
and body districts, where it exerts different functions mainly related to lipid metabolism, with …
and body districts, where it exerts different functions mainly related to lipid metabolism, with …
[HTML][HTML] Obicetrapib as an Adjunct to Stable Statin Therapy in Japanese Subjects: Results from a Randomized Phase 2 Trial
M Harada-Shiba, MH Davdison… - … of Atherosclerosis and …, 2024 - jstage.jst.go.jp
Aims: Obicetrapib is a highly selective cholesteryl ester transfer protein (CETP) inhibitor
shown to reduce low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) …
shown to reduce low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) …
The current state of apolipoprotein E in dyslipidemia
KL Rasmussen, R Frikke-Schmidt - Current Opinion in Lipidology, 2024 - journals.lww.com
ApoE plays an important and well established role in dyslipidemia, vascular disease, and
dementia. Recent evidence from large general population studies now also suggests that …
dementia. Recent evidence from large general population studies now also suggests that …
[HTML][HTML] ApoE enhances mitochondrial metabolism via microRNA-142a/146a-regulated circuits that suppress hematopoiesis and inflammation in hyperlipidemia
Apolipoprotein E (ApoE) is recognized for its pleiotropic properties that suppress
inflammation. We report that ApoE serves as a metabolic rheostat that regulates microRNA …
inflammation. We report that ApoE serves as a metabolic rheostat that regulates microRNA …
[HTML][HTML] Association between Polymorphism rs61876744 in PNPLA2 Gene and Keratoconus in a Saudi Cohort
The genetic etiology of Keratoconus (KC) in Middle Eastern Arabs of Saudi origin is still
unclear. A recent genome-wide study identified two significant loci in the region of PNPLA2 …
unclear. A recent genome-wide study identified two significant loci in the region of PNPLA2 …