[HTML][HTML] Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

FinO/ProQ-family proteins: an evolutionary perspective

Z Liao, A Smirnov - Bioscience reports, 2023 - portlandpress.com
RNA-binding proteins are key actors of post-transcriptional networks. Almost exclusively
studied in the light of their interactions with RNA ligands and the associated functional …

(P) ppGpp synthetase Rsh participates in rifampicin tolerance of persister cells in Brucella abortus in vitro

X Liu, P Wang, Y Shi, Y Cui, S Li, GW Dong, J Li… - Microbial …, 2023 - Elsevier
Brucella abortus is facultative intracellular pathogen that causes chronic persistent infections
and results in abortion and infertility in food animals. Recurrent infections can be one of the …

The FinO/ProQ-like protein PA2582 impacts antimicrobial resistance in Pseudomonas aeruginosa

A Cianciulli Sesso, A Resch, I Moll, U Bläsi… - Frontiers in …, 2024 - frontiersin.org
Bacteria employ small regulatory RNAs (sRNA) and/or RNA binding proteins (RBPs) to
respond to environmental cues. In Enterobacteriaceae, the FinO-domain containing RBP …

[PDF][PDF] Improved RNA stability estimation through bayesian modeling reveals most bacterial transcripts have sub-minute half-lives

L Jenniches, C Michaux, S Reichardt, J Vogel… - bioRxiv, 2023 - biorxiv.org
RNA decay is a crucial mechanism for regulating gene expression in response to
environmental stresses. In bacteria, RNA-binding proteins (RBPs) are known to be involved …

Improved RNA stability estimation through Bayesian modeling reveals most Salmonella transcripts have subminute half-lives

L Jenniches, C Michaux, L Popella… - Proceedings of the …, 2024 - National Acad Sciences
RNA decay is a crucial mechanism for regulating gene expression in response to
environmental stresses. In bacteria, RNA-binding proteins (RBPs) are known to be involved …

Decoding Bacterial Persistence: Mechanisms and Strategies for Effective Eradication

A Sett, V Dubey, S Bhowmik… - ACS Infectious Diseases, 2024 - ACS Publications
The ability of pathogenic bacteria to evade antibiotic treatment is an intricate and
multifaceted phenomenon. Over the years, treatment failure among patients due to …

The (p)ppGpp synthetase Rsh promotes rifampicin tolerant persister cell formation in Brucella abortus by regulating the type II toxin-antitoxin module mbcTA

X Liu, P Wang, N Yuan, Y Zhai, Y Yang, M Hao… - Frontiers in …, 2024 - frontiersin.org
Persister cells are transiently tolerant to antibiotics and are associated with recalcitrant
chronic infections due to recolonization of host cells after antibiotic removal. Brucella spp …

Contribution of the gyrA and waaG mutants to fluoroquinolones resistance, biofilm development, and persister cells formation in Salmonella enterica serovar Typhi

UF Khan, G Habib, H Gul, A Hayat, MU Rehman - Gene, 2024 - Elsevier
Fluoroquinolone resistance in Salmonella has been reported worldwide and poses a
serious public health threat in developing countries. Multiple factors contribute to …