Carbon monoxide (CO) poisoning leads to 50,000–100,000 emergency room visits and
1,500–2,000 deaths each year in the United States alone. Even with treatment, survivors …

Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …

Ischemia or hypoxia can lead to pathological changes in the metabolism and function of
tissues and then lead to various diseases. Timely and effective blood resuscitation or …

Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are three
endogenously produced gases with important functions in the vasculature, immune defense …

Carbon monoxide is an important gasotransmitter in mammals, with pleiotropic therapeutic
potential against a wide range of human diseases. However, clinical translation of CO is …

Carbon monoxide (CO) plays a multifaceted role in the physiology of organisms, from poison
to signaling molecule. Heme proteins, including terminal oxidases, are plausible CO targets …

Carbon monoxide (CO) is endogenously produced in mammals, with blood concentrations
in the high micromolar range in the hemoglobin-bound form. Further, CO has shown …

As one of the triumvirate of recognized gasotransmitter molecules, namely NO, H2S, and
CO, the physiological effects of CO and its potential as a biomarker have been widely …

The dopaminergic system plays important roles in neuromodulation, including prominent
roles in complex neurological functions such as cognition, reward, motivation, and memory …

With the recognition of the endogenous signaling roles and pharmacological functions of
carbon monoxide (CO), there is an increasing need to understand CO's mechanism of …