The incidence of infections caused by bacteria that are resistant to antibiotics is constantly
increasing. In Europe alone, it has been estimated that each year about 33′ 000 deaths are …

Introduction: Prolactin (PRL) exerts inflammatory and anti-inflammatory properties and is
also thought to play an important role in the pathogenesis of neurodegenerative diseases …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Prolonged infusion of beta-lactam antibiotics for Gram-negat... : Current Opinion in
Infectious Diseases Prolonged infusion of beta-lactam antibiotics for Gram-negative …

Background/purpose The rapid emergence of Pseudomonas aeruginosa resistance made
selecting antibiotics more challenge. Antimicrobial stewardship programs (ASPs) are urging …

Extended infusion of piperacillin/tazobactam over 4 h has been proposed as an alternate
mode of administration to the 30-min intermittent infusion to optimize treatment effects in …

Introduction In order to compare the clinical efficacy and safety of prolonged versus
intermittent antipseudomonal beta-lactam antibiotic infusion for the treatment of severe acute …

Abstract Background and Objective Piperacillin is a broad-spectrum β-lactam antibiotic
commonly prescribed in intensive care units. Many piperacillin population pharmacokinetic …

Objectives To explore extracorporeal membrane oxygenation (ECMO)-related alterations of
the pharmacokinetics (PK) of piperacillin/tazobactam and determine an optimal dosage …

Introduction In the past 15 years, treatment of ventilator-associated pneumonia (VAP)
caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) has represented an …