Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

[HTML][HTML] Parasite recognition and signaling mechanisms in innate immune responses to malaria

DC Gowda, X Wu - Frontiers in immunology, 2018 - frontiersin.org
Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …

Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution

X Su, KD Lane, L Xia, JM Sá… - Clinical microbiology …, 2019 - Am Soc Microbiol
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

Malaria-associated acute kidney injury in African children: prevalence, pathophysiology, impact, and management challenges

A Batte, Z Berrens, K Murphy, I Mufumba… - … of Nephrology and …, 2021 - Taylor & Francis
Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance
associated with substantial morbidity and mortality in African children with severe malaria …

Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

J Storm, JS Jespersen, KB Seydel… - EMBO Molecular …, 2019 - embopress.org
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria

A Najer, J Kim, C Saunders, J Che, J Baum… - ACS Infectious …, 2024 - ACS Publications
Severe malaria is a life-threatening condition that is associated with a high mortality. Severe
Plasmodium falciparum infections are mediated primarily by high parasitemia and binding of …

Severe malaria: update on pathophysiology and treatment

JA Brejt, LM Golightly - Current Opinion in Infectious Diseases, 2019 - journals.lww.com
Despite advances in our understanding of malarial pathogenesis much remains unknown.
Antimalarial agents eradicate parasites but no treatments are available to prevent or …

[HTML][HTML] CD36—A host receptor necessary for malaria parasites to establish and maintain infection

A Bachmann, NG Metwally, J Allweier, J Cronshagen… - Microorganisms, 2022 - mdpi.com
Plasmodium falciparum-infected erythrocytes (Pf IEs) present P. falciparum erythrocyte
membrane protein 1 proteins (Pf EMP1s) on the cell surface, via which they cytoadhere to …