Multiple sclerosis (MS) is a chronic disease of the CNS that is characterized by inflammation,
demyelination and axonal injury. Although the etiology of MS is still unknown, many findings …

▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …

Viral infections are though to play an important role in the pathogenesis of multiple sclerosis
(MS) potentially through molecular mimicry. An identical sequence was found in both myelin …

A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections.
However, information about TCR repertoires to defined viral antigens is limited. We …

Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS. Although the
aetiology of multiple sclerosis is still unknown, it is widely believed that T cells play a central …

Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte
antigen (HLA)-DR2 (DRB1* 1501) haplotype. The structure of HLA-DR2 was determined …

T cell recognition is initiated by the binding of TCRs to peptide-MHCs (pMHCs), the
interaction being characterized by weak affinity and fast kinetics. Previously, only 16 natural …

Although multiple sclerosis (MS) patients and healthy individuals have similar frequencies of
myelin basic protein (MBP)-specific T cells, the activation state of these cells has not been …

The immunodominant antimitochondrial antibody response in patients with primary biliary
cirrhosis (PBC) is directed against the E2 component of the pyruvate dehydrogenase …

The question of the cause and the mechanisms of disease in chronic Trypanosoma cruzi
infection continues to attract debate. Chagas disease, characterized by cardiomyopathy …