Control of persistently infecting viruses requires that antiviral CD8+ T cells sustain their
numbers and effector function. In this study, we monitored epitope-specific CD8+ T cells …

Stroke may be accompanied by immunological consequences including local autoimmunity
and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the …

Molecular diversity lies at the heart of adaptive immunity. T‐cell receptors and peptide‐major
histocompatibility complex molecules utilize and rely upon an enormous degree of diversity …

The immune system's ability to distinguish self from nonself is essential for both host defence
against microbial antigens and protection of self-antigens from autoimmune destruction …

Over the past few years, increasing evidence has accumulated to implicate infectious agents
in the etiology of systemic sclerosis (SSc) and Raynaud phenomenon. Infection rates in …

The identification of an agonist peptide (YLSGADLNL, designated CAP1‐6D) to an
immunodominant cytotoxic T‐lymphocyte (CTL) epitope (designated CAP1) of human …

Infection of SJL mice with wild-type BeAn strain of Theiler's murine encephalomyelitis virus
(TMEV) leads to CD4+ T cell-mediated CNS demyelination characterized by the …

Pre-existing immunity to AAV capsid may compromise the safety and efficiency of rAAV-
mediated gene transfer in patients. Anti-capsid cytotoxic immune responses have proven to …

Molecular mimicry has been suggested as a mode of autoreactive T cell stimulation in
autoimmune diseases. Myelin basic protein (MBP) peptide 1–11 induces experimental …

Two main etiological components are considered important in human autoimmune diseases
including multiple sclerosis (MS), first the immunogenetic background and second …