The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide,
and the identification of novel therapeutic strategies for prevention and treatment is urgently …

Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the
world's population. The etiology of RA remains unknown. It is considered to occur in the …

The intestinal epithelium acts as a key defensive barrier that protects internal organs from
the detrimental gut environment. The homeostasis of the gut epithelium may be altered by …

Circular RNAs (circRNAs) have been demonstrated to play crucial roles in the development
and progression of various types of cancers by serving as microRNA sponges to regulate …

Autoimmune diseases are still considered to be pressing concerns due the fact that they are
leaders in death and disability causes worldwide. Resveratrol is a polyphenol derived from a …

In recent years, epigenetic modifications have been widely researched. As humans age,
environmental and genetic factors may drive inflammation and immune responses by …

Rheumatoid arthritis (RA) is a systemic autoimmune disease. Synovial hyperplasia and
persistent inflammation serve as its typical pathological manifestations, which ultimately lead …

Macrophages are crucially involved in the pathogenesis of rheumatoid arthritis (RA).
Macrophages of the M1 phenotype act as pro-inflammatory mediators in synovium, whereas …

Silibinin, a natural polyphenolic flavonoid, possesses anti-oxidant, anti-inflammation and
anti-cancer properties. The present study was designed to investigate the effects of silibinin …