Women manifest more severe COPD symptoms across the life course
Background Previous studies suggest that gender differences exist in COPD diagnosis and
symptoms; these differences may be more pronounced in younger adults. Our objective was …
symptoms; these differences may be more pronounced in younger adults. Our objective was …
Coronary artery and thoracic calcium on noncontrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort
Objective Coronary artery calcification (CAC) and thoracic aortic calcification,(TAC) are
frequently detected on ungated multidetector computed tomography (MDCT) performed for …
frequently detected on ungated multidetector computed tomography (MDCT) performed for …
Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of …
NM deSouza, E Achten, A Alberich-Bayarri… - Insights into …, 2019 - Springer
Observer-driven pattern recognition is the standard for interpretation of medical images. To
achieve global parity in interpretation, semi-quantitative scoring systems have been …
achieve global parity in interpretation, semi-quantitative scoring systems have been …
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
Quantitative computed tomography in chronic obstructive pulmonary disease
DA Lynch, MA Al-Qaisi - Journal of thoracic imaging, 2013 - journals.lww.com
Quantitative computed tomography is being increasingly used to quantify the features of
chronic obstructive pulmonary disease, specifically emphysema, air trapping, and airway …
chronic obstructive pulmonary disease, specifically emphysema, air trapping, and airway …
Discriminative accuracy of the CAPTURE tool for identifying chronic obstructive pulmonary disease in US primary care settings
Importance Chronic obstructive pulmonary disease (COPD) is underdiagnosed in primary
care. Objective To evaluate the operating characteristics of the CAPTURE (COPD …
care. Objective To evaluate the operating characteristics of the CAPTURE (COPD …
Multiple biomarkers predict disease severity, progression and mortality in COPD
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease
characterized by multiple subtypes and variable disease progression. Blood biomarkers …
characterized by multiple subtypes and variable disease progression. Blood biomarkers …
GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing
R Mathur, F Fang, N Gaddis, DB Hancock… - Communications …, 2022 - nature.com
Genome-wide association studies (GWAS) have made impactful discoveries for complex
diseases, often by amassing very large sample sizes. Yet, GWAS of many diseases remain …
diseases, often by amassing very large sample sizes. Yet, GWAS of many diseases remain …
Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
Chronic obstructive pulmonary disease (COPD) is a complex disease at the clinical, cellular,
and molecular levels. However, its diagnosis, assessment, and therapeutic management are …
and molecular levels. However, its diagnosis, assessment, and therapeutic management are …
Clinical epidemiology of COPD: insights from 10 years of the COPDGene study
The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter,
longitudinal analysis of> 10,000 subjects, including smokers with a≥ 10 pack-year history …
longitudinal analysis of> 10,000 subjects, including smokers with a≥ 10 pack-year history …