Pathogenesis of autoimmune disease
DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
[HTML][HTML] From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
JL Casanova, L Abel - Cell, 2022 - cell.com
The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
[HTML][HTML] Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …
[HTML][HTML] Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in∼ 40% of patients
A Gervais, F Rovida, MA Avanzini, S Croce… - The Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but
can cause encephalitis in< 1% of infected individuals. We show that∼ 35% of patients …
can cause encephalitis in< 1% of infected individuals. We show that∼ 35% of patients …
Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia
HC Su, H Jing, Y Zhang… - Annual Review of …, 2023 - annualreviews.org
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
[HTML][HTML] Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
P Bastard, A Gervais, M Taniguchi, L Saare… - The Journal of …, 2024 - ncbi.nlm.nih.gov
Abstract We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …
Molecular mimicry and autoimmunity in the time of COVID-19
M Rojas, M Herrán, C Ramírez-Santana… - Journal of …, 2023 - Elsevier
Infectious diseases are commonly implicated as potential initiators of autoimmune diseases
(ADs) and represent the most commonly known factor in the development of autoimmunity in …
(ADs) and represent the most commonly known factor in the development of autoimmunity in …
Anti-cytokine autoantibodies: mechanistic insights and disease associations
A Cheng, SM Holland - Nature Reviews Immunology, 2024 - nature.com
Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease
severity in infection, inflammation and autoimmunity. By reducing or augmenting cytokine …
severity in infection, inflammation and autoimmunity. By reducing or augmenting cytokine …
Reconciling mouse and human immunology at the altar of genetics
P Gros, JL Casanova - Annual Review of Immunology, 2023 - annualreviews.org
Immunity to infection has been extensively studied in humans and mice bearing naturally
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …