The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …

Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …

The contribution of nerves to the pathogenesis of malignancies has emerged as an
important component of the tumour microenvironment. Recent studies have shown that …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

The genetic landscape of classical myeloproliferative neoplasm (MPN) is in large part
elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament
initially characterized in neural stem cells. However, current extensive evidence obtained in …