Pyroptosis: mechanisms and diseases
P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …
innate immunity and disease. The research scope of pyroptosis has expanded with the …
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …
guidelines for the definition and interpretation of cell death from morphological, biochemical …
[HTML][HTML] Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
X Han, T Xu, Q Fang, H Zhang, L Yue, G Hu, L Sun - Redox Biology, 2021 - Elsevier
Activated microglia are an important type of innate immune cell in the brain, and they secrete
inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding …
inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding …
Mechanisms and treatment of organ failure in sepsis
C Lelubre, JL Vincent - Nature Reviews Nephrology, 2018 - nature.com
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …
The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review
X Zheng, W Chen, F Gong, Y Chen, E Chen - Frontiers in immunology, 2021 - frontiersin.org
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …
response to infection. Recently was been found that pyroptosis is a unique form of …
Mechanism and regulation of pyroptosis-mediated in cancer cell death
J Ruan, S Wang, J Wang - Chemico-biological interactions, 2020 - Elsevier
Pyroptosis, a form of programmed cell death, has garnered increasing attention as it relates
to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing …
to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing …
Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions
RA Aglietti, EC Dueber - Trends in immunology, 2017 - cell.com
Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …
Ceria–Zirconia nanoparticles as an enhanced multi‐antioxidant for sepsis treatment
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in
scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for …
scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for …
Mechanism of membrane pore formation by human gasdermin‐D
E Mulvihill, L Sborgi, SA Mari, M Pfreundschuh… - The EMBO …, 2018 - embopress.org
Abstract Gasdermin‐D (GSDMD), a member of the gasdermin protein family, mediates
pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts …
pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts …
[HTML][HTML] Intracellular and extracellular lipopolysaccharide signaling in sepsis: avenues for novel therapeutic strategies
RS Gabarin, M Li, PA Zimmel, JC Marshall… - Journal of innate …, 2021 - karger.com
Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to
infection. During gram-negative bacterial infection and other acute illness such as …
infection. During gram-negative bacterial infection and other acute illness such as …