1, 4-Dihydropyridine: a dependable heterocyclic ring with the promising and the most anticipable therapeutic effects

AP Mishra, A Bajpai, AK Rai - Mini reviews in medicinal …, 2019 - ingentaconnect.com
Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal
chemistry. Among all of the heterocyclic scaffolds, 1, 4-Dihydropyridine (1, 4-DHP) is one of …

Chronic baroreflex activation: a potential therapeutic approach to heart failure with preserved ejection fraction

D Georgakopoulos, WC Little, WT Abraham… - Journal of cardiac …, 2011 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) is a substantial public health issue,
equal in magnitude to heart failure with reduced ejection fraction. Clinical outcomes of …

SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization

EB Basalious, N Shawky, SM Badr-Eldin - International journal of …, 2010 - Elsevier
The aim of this study was to develop and optimize SNEDDS formulations containing
surfactants reported to be bioenhancers for improvement of dissolution and oral absorption …

Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization

R Gannu, CR Palem, VV Yamsani, SK Yamsani… - International journal of …, 2010 - Elsevier
The purpose of the present study was to develop and optimize the microemulsion based
transdermal therapeutic system for lacidipine (LCDP), a poorly water soluble and low …

Formulation and optimization of lacidipine loaded niosomal gel for transdermal delivery: in-vitro characterization and in-vivo activity

M Qumbar, SS Imam, J Ali, J Ahmad, A Ali - Biomedicine & …, 2017 - Elsevier
The aim of the present research work is to formulate lacidipine (LAC) loaded niosomes
formulation for the management of hypertension by thin film hydration technique. The …

Late‐Stage Diversification of Non‐Steroidal Anti‐Inflammatory Drugs by Transition Metal‐Catalyzed C–H Alkenylations, Thiolations and Selenylations

W Ma, H Dong, D Wang… - Advanced Synthesis & …, 2017 - Wiley Online Library
Ruthenium‐and silver‐catalyzed selective C–H alkenylations, thiolations and selenylations
of phenazone (antipyrine)–a non‐steroidal anti‐inflammatory drug–have been developed …

Screening and identification of Lassa virus entry inhibitors from an FDA-approved drug library

P Wang, Y Liu, G Zhang, S Wang, J Guo, J Cao… - Journal of …, 2018 - Am Soc Microbiol
Lassa virus (LASV) belongs to the Mammarenavirus genus (family Arenaviridae) and
causes severe hemorrhagic fever in humans. At present, there are no Food and Drug …

The role of existing and newer calcium channel blockers in the treatment of hypertension

J Basile - The Journal of Clinical Hypertension, 2004 - Wiley Online Library
Calcium channel blockers (CCBs), which include both dihydropyridines such as nifedipine
and amlodipine and non‐dihydropyridines (verapamil and diltiazem), are among the most …

[HTML][HTML] Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications

J Sun, T Yogarajah, RCH Lee, P Kaur, M Inoue… - Scientific Reports, 2020 - nature.com
Abstract Enterovirus A71 (EV-A71) is one of the aetiological agents for the hand, foot and
mouth disease (HFMD) in young children and a potential cause of neurological …

Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 23 factorial design and in vivo evaluation in rabbits

SM Soliman, NS Abdelmalak, ON El-Gazayerly… - Drug …, 2016 - Taylor & Francis
Context: Proniosomes offer a versatile vesicle drug delivery concept with potential for
delivery of drugs via transdermal route. Objectives: To develop proniosomal gel using …