Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Recent strategies for the treatment of cancer, other than just tumor cell killing have been
under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis …

Head and neck squamous cell carcinoma (HNSCC) arises from the epithelial lining of the
oral cavity, hypopharynx, oropharynx, and larynx. There are several potential risk factors that …

In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the
interactions of tumor cells with their microenvironment. Recent technological advances in …

To investigate late toxicity among patients with newly-diagnosed brain metastases
undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or …

Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of
morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5 …

Hypoxia is an important pathological hallmark of the tumor microenvironment, associated
with metabolic alterations, cell proliferation, aggressiveness, metastasis, and therapy …

Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides
tumor progression and poses barriers to the efficacy of cancer therapies. Most common …

Despite the development of standard therapies, including surgery, radiotherapy and
chemotherapy, survival rates for head and neck squamous cell carcinoma (HNSCC) have …

Combination therapy has been conferred with manifold assets leveraging the synergy of
different agents to achieve a sufficient therapeutic outcome with lower administered drug …