Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems

H Weerasinghe, H Stölting, AJ Rose… - … and Molecular Biology …, 2024 - journals.asm.org
The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …

Exploring emerging drug responses in Cryptococcus

W Liu, Y Gao, C Ding - Trends in Microbiology, 2024 - cell.com
Cryptococcosis imposes a considerable burden on public health, and emerging drug
responses to anticryptococcal drugs remain to be addressed. In this forum article we discuss …

With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in Cryptococcus neoformans

K Yoo, S Bhattacharya, NK Oliveira, N Pereira de Sa… - mBio, 2024 - journals.asm.org
Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-
threatening meningoencephalitis. During the infection, the microbial population is …

Population heterogeneity in Cryptococcus neoformans: Impact on pathogenesis

R Agrawal, RJA de Castro, A Sturny-Leclère… - PLoS …, 2024 - journals.plos.org
Cryptococcus neoformans was first isolated from a patient in 1894 [1] and 130 years later, it
remains a prevalent global threat, especially for people living with human immunodeficiency …

Penetration Profile of Terbinafine Compared to Amorolfine in Mycotic Human Toenails Quantified by Matrix-Assisted Laser Desorption Ionization–Fourier Transform …

N Joly-Tonetti, R Legouffe, A Tomezyk… - Infectious Diseases and …, 2024 - Springer
Introduction Amorolfine 5% lacquer is an established topical treatment for fungal infection of
the nails. The success of topical therapy for onychomycosis depends on whether the …