Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …

Background: A key cause of the high mortality of cardiovascular diseases is the
cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement …

The progression from cardiac injury to symptomatic heart failure has been intensely studied
over the last decade, and is largely attributable to a loss of functional cardiac myocytes …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose
tissue, is a devastating complication of cancer and other chronic diseases. Interleukin-6 and …

Rationale: The role of interleukin (IL)-6 in the pathogenesis of cardiac myocyte hypertrophy
remains controversial. Objective: To conclusively determine whether IL-6 signaling is …

Heart failure is a highly morbid and mortal clinical condition that represents the last stage of
most cardiovascular disorders. Diabetes is strongly associated with an increased incidence …

▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …

Lethal reperfusion injury is now recognized as a major limitation of current reperfusion
therapy by primary percutaneous coronary intervention for acute myocardial infarction …