Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

Spatial navigation and memory are often seen as heavily intertwined at the cognitive and
neural levels of analysis. We review models that hypothesize a central role for the medial …

Alzheimer's disease researchers have been intrigued by the selective regional vulnerability
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …

Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization.
Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown …

This review focuses on possible contributions of neural dedifferentiation to age-related
cognitive decline. Neural dedifferentiation is held to reflect a breakdown in the functional …

To explain how the brain orchestrates information-processing for cognition, we must
understand information itself. Importantly, information is not a monolithic entity. Information …

Aging is associated with functional activation changes in domain-specific regions and large-
scale brain networks. This preregistered Functional magnetic resonance imaging (fMRI) …

Neural activation patterns in the ventral visual cortex in response to different categories of
visual stimuli (eg, faces vs. houses) are less selective, or distinctive, in older adults than in …

Older adults' difficulty in distinguishing between old and new information contributes to
memory decline, which may occur because older adults are less likely than young adults to …

Age-related episodic memory decline is characterized by striking heterogeneity across
individuals. Hippocampal pattern completion is a fundamental process supporting episodic …