Apolipoprotein B: mRNA editing, lipoprotein assembly, and presecretory degradation
NO Davidson, GS Shelness - Annual review of nutrition, 2000 - annualreviews.org
Apolipoprotein (apo) B circulates in two distinct forms, apoB100 and apoB48. Human liver
secretes apoB100, the product of a large mRNA encoding 4536 residues. The small …
secretes apoB100, the product of a large mRNA encoding 4536 residues. The small …
Intestinal bile acid transport: biology, physiology, and pathophysiology
BL Shneider - Journal of pediatric gastroenterology and nutrition, 2001 - journals.lww.com
Bile acid homeostasis, which is a critical part of human health, involves hepatic biosynthesis
and vectorial transport of bile acids in a number of organs (Fig. 1). Bile acids are synthesized …
and vectorial transport of bile acids in a number of organs (Fig. 1). Bile acids are synthesized …
[HTML][HTML] Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
ER Blasi, R Rocha, AE Rudolph, EAG Blomme… - Kidney international, 2003 - Elsevier
Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Background
We evaluated the role of aldosterone as a mediator of renal inflammation and fibrosis in a rat …
We evaluated the role of aldosterone as a mediator of renal inflammation and fibrosis in a rat …
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
M Raabe, MM Véniant, MA Sullivan… - The Journal of …, 1999 - Am Soc Clin Investig
A deficiency in microsomal triglyceride transfer protein (MTP) causes the human lipoprotein
deficiency syndrome abetalipoproteinemia. However, the role of MTP in the assembly and …
deficiency syndrome abetalipoproteinemia. However, the role of MTP in the assembly and …
Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL …
The subendothelial retention of LDLs through their interaction with proteoglycans has been
proposed to be a key process in the pathogenesis of atherosclerosis. In vitro studies have …
proposed to be a key process in the pathogenesis of atherosclerosis. In vitro studies have …
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
The importance of cholesterol ester synthesis by acyl CoA: cholesterol acyltransferase
(ACAT) enzymes in intestinal and hepatic cholesterol metabolism has been unclear. We …
(ACAT) enzymes in intestinal and hepatic cholesterol metabolism has been unclear. We …
Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial …
J Borén, I Lee, W Zhu, K Arnold… - The Journal of …, 1998 - Am Soc Clin Investig
Familial defective apolipoprotein B100 (FDB) is caused by a mutation of apo-B100
(R3500Q) that disrupts the receptor binding of low density lipoproteins (LDL), which leads to …
(R3500Q) that disrupts the receptor binding of low density lipoproteins (LDL), which leads to …
Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes
M Raabe, LM Flynn, CH Zlot, JS Wong… - Proceedings of the …, 1998 - National Acad Sciences
Abetalipoproteinemia, an inherited human disease characterized by a near-complete
absence of the apolipoprotein (apo) B-containing lipoproteins in the plasma, is caused by …
absence of the apolipoprotein (apo) B-containing lipoproteins in the plasma, is caused by …
Target-specific gene silencing of layer-by-layer assembled gold–cysteamine/siRNA/PEI/HA nanocomplex
Target-specific intracellular delivery of small interfering RNA (siRNA) is regarded as one of
the most important technologies for the development of siRNA therapeutics. In this work, a …
the most important technologies for the development of siRNA therapeutics. In this work, a …
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
The liver secretes triglyceride-rich VLDLs, and the triglycerides in these particles are taken
up by peripheral tissues, mainly heart, skeletal muscle, and adipose tissue. Blocking hepatic …
up by peripheral tissues, mainly heart, skeletal muscle, and adipose tissue. Blocking hepatic …