Co‐administration of artemether–lumefantrine with milk is recommended to improve
lumefantrine (L) absorption but milk may not be available in resource‐limited settings. This …

Cytochrome P450 enzymes play a central role in the phase I biotransformation process of a
wide range of compounds, including xenobiotics, drugs, hormones and vitamins. It is …

Aim: To investigate the potential involvement of the hepatic ATP-binding cassette
transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with …

Artemether‐lumefantrine (AL) is a first‐line treatment for uncomplicated malaria. Absorption
of lumefantrine (LUM) is fat dependent, and in children, intake is recommended with milk …

Abstract Amodiaquine (AQ) is a 4‐aminoquinoline widely used in the treatment of malaria as
part of the artemisinin combination therapy (ACT). AQ is metabolised towards its main …

The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose
combination of artemether‐lumefantrine, the most widely adopted artemisinin combination …

A simple, precise and sensitive high performance thin layer chromatographic (HPTLC)
method has been developed and validated for drug of choice Lumefantrine in treatment of …

Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus
Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become …

Cyclosporine (CsA) and tacrolimus are immunosuppressants used for the prevention of
rejection of transplanted organs. The genes encoding cytochrome (CYP) P450 enzymes …

Herbal remedies are an important and often-used commodity in developing countries, such
as those in Africa. There is a long-standing belief that these medicinal preparations are more …