Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Stroke risk prediction with machine learning techniques

E Dritsas, M Trigka - Sensors, 2022 - mdpi.com
A stroke is caused when blood flow to a part of the brain is stopped abruptly. Without the
blood supply, the brain cells gradually die, and disability occurs depending on the area of …

Systemic inflammation after stroke: implications for post‐stroke comorbidities

A Simats, A Liesz - EMBO molecular medicine, 2022 - embopress.org
Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

AG Spiteri, CL Wishart, R Pamphlett, G Locatelli… - Acta …, 2022 - Springer
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

A systematic review of the incidence, prevalence, costs, and activity and work limitations of amputation, osteoarthritis, rheumatoid arthritis, back pain, multiple sclerosis …

J Lo, L Chan, S Flynn - Archives of physical medicine and rehabilitation, 2021 - Elsevier
Objectives To present recent evidence on the prevalence, incidence, costs, activity
limitations, and work limitations of common conditions requiring rehabilitation. Data Sources …

A DNA Nanostructure-Based Neuroprotectant against Neuronal Apoptosis via Inhibiting Toll-like Receptor 2 Signaling Pathway in Acute Ischemic Stroke

M Zhou, T Zhang, B Zhang, X Zhang, S Gao, T Zhang… - ACS …, 2021 - ACS Publications
Ischemic stroke is a main cause of cognitive neurological deficits and disability worldwide
due to a plethora of neuronal apoptosis. Unfortunately, numerous neuroprotectants for …

Excitotoxicity: still hammering the ischemic brain in 2020

DW Choi - Frontiers in neuroscience, 2020 - frontiersin.org
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

Acute stroke in times of the COVID-19 pandemic: a multicenter study

C Hoyer, A Ebert, HB Huttner, V Puetz, B Kallmünzer… - Stroke, 2020 - Am Heart Assoc
Background and Purpose: This study aims to assess the number of patients with acute
ischemic cerebrovascular events seeking in-patient medical emergency care since the …