We propose a weight-neutral strategy for obesity treatment on the following grounds:(1) the
mortality risk associated with obesity is largely attenuated or eliminated by moderate-to-high …

Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver
disease, are characterized by chronic low-grade tissue and systemic inflammation. During …

The interaction between insulin and exercise is an example of balancing and modifying the
effects of two opposing metabolic regulatory forces under varying conditions. While insulin is …

In obesity, excessive abdominal fat, especially the accumulation of visceral adipose tissue
(VAT), increases the risk of metabolic disorders, such as type 2 diabetes mellitus (T2DM) …

The prevalence of obesity continues to rise worldwide despite evidence-based public health
recommendations. The promise to adopt a healthy lifestyle is increasingly important for …

White adipose tissue (WAT) is important for metabolic homeostasis. We established the
differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and …

Excessive adipose tissue mass underlies much of the metabolic health complications in
obesity. Although exercise training is known to improve metabolic health in individuals with …

Background Exercise exerts many health benefits by directly inducing molecular alterations
in physically utilized skeletal muscle. Molecular adaptations of subcutaneous adipose tissue …

Lifestyle therapy (energy restriction and exercise) is the cornerstone of therapy for people
with type 2 diabetes (T2D) but is difficult to implement. We conducted an 8-month …

Exercise is a powerful and effective preventive measure against chronic diseases by
increasing energy expenditure and substrate mobilization. Long-duration acute exercise …