Improper activation of the immune system contributes to a variety of clinical conditions,
including autoimmune and allergic diseases as well as solid organ and bone marrow …

Autoimmunity is caused by an unbalanced immune system, giving rise to a variety of organ-
specific to system disorders. Patients with autoimmune diseases are commonly treated with …

It is hypothesized that CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) can prevent
destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present …

OBJECTIVE Type 1 diabetes is a condition in which pancreatic islets are destroyed by self-
reactive T cells. The process is facilitated by deficits in the number and suppressive activity …

Cell-based immunotherapies can provide safe and effective treatments for various disorders
including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral …

Background aims Mouse models indicate that adoptive transfer of regulatory T cells (Treg)
may suppress graft-versus-host-disease (GvHD) while preserving graft-versus-leukemia …

Rationale: Neuroinflammation is a primary feature of Alzheimer's disease (AD), for which an
increasing number of drugs have been specifically developed. The present study aimed to …

Strategies to prevent organ transplant rejection whilst minimizing long-term
immunosuppression are currently under intense investigation with regulatory T cells (Tregs) …

Treg therapy holds promise as a potentially curative approach to establish immune
tolerance in transplantation and autoimmune disease. An outstanding question is whether …

Regulatory T cell (Treg) therapy is a promising curative approach for a variety of immune-
mediated conditions. CRISPR-based genome editing allows precise insertion of transgenes …