Interleukin‐17 as a spatiotemporal bridge from acute to chronic inflammation: Novel insights from computational modeling
A systematic review of several acute inflammatory diseases ranging from sepsis and
trauma/hemorrhagic shock to the relevant pathology of the decade, COVID‐19, points to the …
trauma/hemorrhagic shock to the relevant pathology of the decade, COVID‐19, points to the …
[HTML][HTML] The Use of Single-Cell RNA-Sequencing and Spatial Transcriptomics in Understanding the Pathogenesis and Treatment of Skin Diseases
AE Houser, A Kazmi, AK Nair, AL Ji - JID Innovations, 2023 - Elsevier
The development of multiomic profiling tools has rapidly expanded in recent years, along
with their use in profiling skin tissues in various contexts, including dermatologic diseases …
with their use in profiling skin tissues in various contexts, including dermatologic diseases …
Physiological roles of human interleukin‐17 family
Y Liu, Y Ouyang, W You, W Liu, Y Cheng… - Experimental …, 2024 - Wiley Online Library
Abstract Interleukin‐17 s (IL‐17s) are well‐known proinflammatory cytokines, and their
antagonists perform excellently in the treatment of inflammatory skin diseases such as …
antagonists perform excellently in the treatment of inflammatory skin diseases such as …
Hypoxia preconditioning of adipose stem cell-derived exosomes loaded in gelatin methacryloyl (GelMA) promote type H angiogenesis and osteoporotic fracture repair
X Li, S Fang, S Wang, Y Xie, Y Xia, P Wang… - Journal of …, 2024 - Springer
The challenges posed by delayed atrophic healing and nonunion stand as formidable
obstacles in osteoporotic fracture treatment. The processes of type H angiogenesis and …
obstacles in osteoporotic fracture treatment. The processes of type H angiogenesis and …
[HTML][HTML] Targeting Type I IFN/STAT1 signaling inhibited and reversed corneal squamous metaplasia in Aire-deficient mouse
Y Yu, S Dou, P Peng, L Ma, X Qi, T Liu, Y Yu… - Pharmacological …, 2023 - Elsevier
Corneal transparency and integrity are essential for obtaining good vision; nevertheless,
squamous metaplasia (SQM) of ocular epithelium is a kind of serious blinding corneal …
squamous metaplasia (SQM) of ocular epithelium is a kind of serious blinding corneal …
IL-17 signaling in skin repair: safeguarding metabolic adaptation of wound epithelial cells
J Wang, X Ding - Signal Transduction and Targeted Therapy, 2022 - nature.com
In a recent paper published in Science, Konieczny et al. describe that IL-17A produced by
RORγt+ γδ T cells governs wound epithelial cell hypoxic adaptation, which is required for …
RORγt+ γδ T cells governs wound epithelial cell hypoxic adaptation, which is required for …
How studies in developmental epithelial-mesenchymal transition and mesenchymal-epithelial transition inspired new research paradigms in biomedicine
Epithelial-mesenchymal transition (EMT) and its reverse mechanism, mesenchymal-
epithelial transition (MET), are evolutionarily conserved mechanisms initially identified in …
epithelial transition (MET), are evolutionarily conserved mechanisms initially identified in …
Interleukin-17A immune pattern across genetic acantholytic and blistering disorders
A Haghighi Javid, D Li… - Clinical and …, 2023 - academic.oup.com
There is a high therapeutic need in acantholytic and blistering genodermatoses. Cutaneous
inflammation is a reasonable therapeutic target, although the patterns are not yet fully …
inflammation is a reasonable therapeutic target, although the patterns are not yet fully …
Immunogenic cell death associated molecular patterns and the dual role of IL17RA in interstitial cystitis/bladder pain syndrome
W Zhang, X Liu, J Wang, X Wang, Y Zhang - Biomolecules, 2023 - mdpi.com
The unclear etiology and pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS)
are responsible for the lack of effective treatment and the poor patient prognosis. Various …
are responsible for the lack of effective treatment and the poor patient prognosis. Various …
IL-17A Orchestrates Reactive Oxygen Species/HIF1a− Mediated Metabolic Reprogramming in Psoriasis
Immune cell− derived IL-17A is one of the key pathogenic cytokines in psoriasis, an
immunometabolic disorder. Although IL-17A is an established regulator of cutaneous …
immunometabolic disorder. Although IL-17A is an established regulator of cutaneous …